N-terminal amino acid sequences in the major capsid proteins of foot-and-mouth disease virus types A, O, and C

N-terminal amino acid sequences in the major capsid proteins of foot-and-mouth disease virus types A, O, and C.

Sequences of amino acids at the N-termini of virus proteins VP1, VP2, and VP3 were determined for foot-and-mouth disease virus types A12 strain 119, O1Brugge and C3Resende. In the polyacrylamide gel electrophoresis system used to purify the proteins, VP3 migrated faster than VP1 or VP2; and in the virion, VP3 could be cleaved by trypsin into VP3a and VP3b. The N-terminal amino acids for each of...

The situation of foot and mouth disease virus types and subtypes in Iran in 1980-1983

amino acid diversity of antigenic sites of iranian type o foot-and-mouth disease virus

foot-and-mouth disease (fmd) is a major cause of endemic outbreaks in livestock in iran. in this study, clinical field samples of foot-and-mouth disease virus were collected from an outbreak in khorasan razavi province during april and august of 2010, and subjected to indirect sandwich elisa and rt-pcr. the viral serotype circulating during the period was confirmed to be type o. the virus was t...

Organic Circulation and persistence of Foot – and – Mouth disease virus type O in guinea pig

Since, the most susceptible laboratory animal to Foot–and–Mouth disease virus (FMDV) is guinea pig, and then one milliliter of FMDV type (O) concentrations of 106-106.5 TCID50was inoculated intradermally (ID) to 10 plantar surface of guinea pig (right side). Guinea pig adapted virus has been prepared after generalization phase, and then one milliliter of virus was inoculated intradermally to 30...

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid resistance.

Foot-and-mouth disease virus (FMDV) particles lose infectivity due to their disassembly at pH values slightly below neutrality. This acid-dependent disassembly process is required for viral RNA release inside endosomes. To study the molecular determinants of viral resistance to acid-induced disassembly, six FMDV variants with increased resistance to acid inactivation were isolated. Infection by...